A method and circuit arrangement for selectively predicating an instruction in an instruction stream based upon a value corresponding to a predication register address indicated by a portion of an operand associated with the instruction. A first compare instruction in an instruction stream stores a compare result in at a register address of a predication register. The register address of the predication register is stored in a portion of an operand associated with a second instruction, and during decoding the second instruction, the predication register is accessed to determine a value stored at the register address of the predication register, and the second instruction is selectively predicated based on the value stored at the register address of the predication register.