An optical system includes a tunable semiconductor light emitter that generates an input beam having a wavelength shorter than about 2.5 microns, an optical isolator coupled to the emitter and configured to block reflected light into the emitter, an optical amplifier receiving the input beam and outputting an intermediate beam, and optical fibers receiving the intermediate beam and forming an output beam. A subsystem includes lenses or mirrors that deliver the output beam to a sample. The subsystem may include an Optical Coherence Tomography (OCT) apparatus having a sample arm and a reference arm, the output beam having a temporal duration greater than approximately 30 picoseconds, a repetition rate between continuous wave and Megahertz or higher, and a time averaged intensity less than approximately 50 MW/cm2. The system may also include a light detection system collecting any of the output beam that reflects or transmits from the sample.