Embodiments include circuits, apparatuses, and systems for programmable memory device sense amplifiers. In embodiments, an electronic circuit may include a programmable memory device having a first resistance in a first state and a second resistance in a second state, a reference element, an amplifier to generate a first output signal based at least in part on the resistance of the programmable memory device and a second output signal based at least in part on a current from the reference element, and a comparator to determine a state of the programmable memory device based on the first and second output signals from the amplifier. Other embodiments may be described and claimed.