Invention Grant
- Patent Title: Sustained release siRNA for ocular drug delivery
- Patent Title (中): 用于眼药物递送的持续释放siRNA
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Application No.: US14608514Application Date: 2015-01-29
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Publication No.: US09480646B2Publication Date: 2016-11-01
- Inventor: Hongwen M. Rivers , Lon T. Spada , Michelle Luu
- Applicant: Allergan, Inc.
- Applicant Address: US CA Irvine
- Assignee: Allergan, Inc.
- Current Assignee: Allergan, Inc.
- Current Assignee Address: US CA Irvine
- Agent Brigitte C. Phan; Ted A. Chan
- Main IPC: A61K47/34
- IPC: A61K47/34 ; A61K47/48 ; A61K31/713 ; C12N15/113 ; A61K9/00 ; A61K31/7088 ; A61K48/00
Abstract:
The present invention provides an ocular implant of siRNA complexed with a transfection agent such as cationic lipids and short cell penetration peptides, wherein the complex is associated with a biocompatible polymer. The biocompatible polymer includes a polymeric matrix configured to release the complex into the eye of a patient at therapeutic levels for a time sufficient to treat an ocular condition or disease.
Public/Granted literature
- US20150141348A1 SUSTAINED RELEASE siRNA FOR OCULAR DRUG DELIVERY Public/Granted day:2015-05-21
Information query
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