Invention Grant
US09480695B2 Methods for inducing orexin neurons and agent for treating narcolepsy or eating disorder
有权
诱导食欲素神经元和治疗发作性睡眠障碍或进食障碍的药物的方法
- Patent Title: Methods for inducing orexin neurons and agent for treating narcolepsy or eating disorder
- Patent Title (中): 诱导食欲素神经元和治疗发作性睡眠障碍或进食障碍的药物的方法
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Application No.: US14224730Application Date: 2014-03-25
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Publication No.: US09480695B2Publication Date: 2016-11-01
- Inventor: Kunio Shiota , Shintaro Yagi , Koji Hayakawa , Mitsuko Hirosawa-Takamori , Daisuke Arai , Keiji Hirabayashi
- Applicant: THE UNIVERSITY OF TOKYO
- Applicant Address: JP Tokyo
- Assignee: The University of Tokyo
- Current Assignee: The University of Tokyo
- Current Assignee Address: JP Tokyo
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: JP2013-062298 20130325
- Main IPC: A61K31/7008
- IPC: A61K31/7008 ; G01N33/50 ; C12Q1/68 ; C12N5/0793
Abstract:
The invention provides a method for producing an orexin neuron by culturing a pluripotent stem cell or a neural progenitor cell in the presence of N-acetyl-D-mannosamine and optionally in the presence of at least one inhibitor selected from the group consisting of a Sirtuin 1 inhibitor and an O-linked β-N-acetylglucosamine transferase inhibitor. The invention also provides a therapeutic agent for narcolepsy or eating disorders, such as anorexia, containing N-acetyl-D-mannosamine, which is based on the induction of orexin neuron in vivo.
Public/Granted literature
- US20140349964A1 METHODS FOR INDUCING OREXIN NEURONS AND AGENT FOR TREATING NARCOLEPSY OR EATING DISORDER Public/Granted day:2014-11-27
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