Invention Grant
US09480726B2 Leukotoxin E/D as a new anti-inflammatory agent and microbicide
有权
白介素E / D作为新型抗炎剂和杀微生物剂
- Patent Title: Leukotoxin E/D as a new anti-inflammatory agent and microbicide
- Patent Title (中): 白介素E / D作为新型抗炎剂和杀微生物剂
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Application No.: US14468026Application Date: 2014-08-25
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Publication No.: US09480726B2Publication Date: 2016-11-01
- Inventor: Victor J. Torres , Derya Unutmaz , Francis Alonzo, III
- Applicant: New York University
- Applicant Address: US NY New York
- Assignee: New York University
- Current Assignee: New York University
- Current Assignee Address: US NY New York
- Agency: LeClairRyan, a Professional Corporation
- Main IPC: A61K38/16
- IPC: A61K38/16 ; A01N37/18 ; C07K16/28 ; A61K45/06 ; A61K31/351 ; A61K31/46 ; A61K31/506 ; A61K31/439 ; A61K39/395
Abstract:
The present invention relates to methods for preventing or treating Human Immunodeficiency Virus (HIV) infection, inflammatory conditions, and graft-versus-host-disease (GVHD) in a subject. Therapeutic compositions of the present invention comprise Leukocidin E (LukE) and/or D proteins or polypeptides. The invention further relates to methods of treating Staphylococcus aureus infection by administering a composition comprising a CCR5 antagonist or any molecule that blocks LukE/D interaction with CCR5+ cells in an amount effective to treat the S. aureus infection in the subject.
Public/Granted literature
- US20150056163A1 LEUKOTOXIN E/D AS A NEW ANTI-INFLAMMATORY AGENT AND MICROBICIDE Public/Granted day:2015-02-26
Information query
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