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US09480750B2 Preparation of antibody or an antibody fragment targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof 有权
用于全身给予治疗剂或诊断剂的抗体或抗体片段靶向免疫脂质体的制备及其用途

Preparation of antibody or an antibody fragment targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
Abstract:
A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprises the steps of (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cationic immunoliposome or with a cationic polymer to form a polyplex; and (c) mixing said cationic immunoliposome or said polyplex with a therapeutic or diagnostic agent to form said antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex.
Abstract(Chinese):

制备抗体或抗体片段靶向阳离子免疫脂质体或聚合物复合物的方法包括以下步骤：（a）制备抗体或抗体片段; （b）将所述抗体或抗体片段与阳离子脂质体混合以形成阳离子免疫脂质体或用阳离子聚合物形成聚合物; 和（c）将所述阳离子免疫脂质体或所述多聚体与治疗剂或诊断剂混合以形成所述抗体或抗体片段靶向阳离子免疫脂质体或聚合物复合物。

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