A variable cutoff cylinder alignment apparatus is provided. The variable cutoff cylinder alignment apparatus includes a plate cylinder support box for supporting an exchangeable variable cutoff plate cylinder, a blanket cylinder support box for supporting an exchangeable variable cutoff blanket cylinder and an alignment stop adapted to align the blanket cylinder support box and the plate cylinder support box. The plate cylinder support box supports an exchangeable plate cam and the blanket cylinder support box includes a blanket cam. The exchangeable plate cam is capable of contacting the stop and the exchangeable blanket cam is capable of contacting the plate support box to align the blanket cylinder support box and the plate cylinder support box. The plate cylinder support box and the blanket cylinder support box are capable of aligning cylinders of different sized cutoffs. A variable cutoff offset printing press and a method of aligning printing cylinders during a cutoff change are also provided.