The tire pressure sensor module contains a casing, a nozzle, a sleeve element, a fastening element, and a two-way tire information transmission and sensory system inside the casing. The casing has a trough and an air opening. The nozzle contains a nozzle mouth and a nozzle base. The nozzle base is joined to the casing, and the mouth is threaded through the sleeve element. The nozzle and the sleeve element are secured to the casing by the fastening element through the trough. The two-way tire information transmission and sensory system contains a battery, a micro-controller circuit, a low-power-consumption Bluetooth wireless transceiver circuit, a boosting/regulating circuit, a pressure sensor, an operation amplifier, a gravity sensor, a temperature sensor, and an antenna.