Invention Grant
US09481661B2 Disubstituted maleic anhydrides with altered kinetics of ring closure
有权
具有改变的闭环动力学的二取代马来酸酐
- Patent Title: Disubstituted maleic anhydrides with altered kinetics of ring closure
- Patent Title (中): 具有改变的闭环动力学的二取代马来酸酐
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Application No.: US14119074Application Date: 2012-05-31
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Publication No.: US09481661B2Publication Date: 2016-11-01
- Inventor: Andrei V Blokhin , David B Rozema , Jonathan D Benson , Jeffrey C Carlson
- Applicant: Andrei V Blokhin , David B Rozema , Jonathan D Benson , Jeffrey C Carlson
- Applicant Address: US WI Madison
- Assignee: Arrowhead Madison, Inc.
- Current Assignee: Arrowhead Madison, Inc.
- Current Assignee Address: US WI Madison
- Agent Kirk Ekena
- International Application: PCT/US2012/040130 WO 20120531
- International Announcement: WO2012/173784 WO 20121220
- Main IPC: C07D307/60
- IPC: C07D307/60 ; C07H15/26 ; C07H15/08 ; C07D307/89
Abstract:
We describe anhydride compounds suitable for physiologically labile modification of amine-containing molecules. The described anhydrides form reversible linkages having desirable kinetics for in vivo delivery of biologically active molecules. Also described are endosomolytic polymers formed by modification of membrane active polyamines with the described anhydrides.
Public/Granted literature
- US20140128584A1 Disubstituted Maleic Anhydrides with Altered Kinetics of Ring Closure Public/Granted day:2014-05-08
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