Invention Grant
- Patent Title: Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
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Application No.: US14255634Application Date: 2014-04-17
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Publication No.: US09481671B2Publication Date: 2016-11-01
- Inventor: Oxana Ibraghimov-Beskrovnaya , Thomas A. Natoli
- Applicant: Genzyme Corporation
- Applicant Address: US MA Cambridge
- Assignee: Genzyme Corporation
- Current Assignee: Genzyme Corporation
- Current Assignee Address: US MA Cambridge
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- Main IPC: A61K31/535
- IPC: A61K31/535 ; A61K31/445 ; A61K31/425 ; A61K31/40 ; C07D417/14 ; A61K31/325 ; A61K31/357 ; A61K31/396 ; A61K31/4025 ; A61K31/403 ; A61K31/4155 ; A61K31/4178 ; A61K31/4192 ; A61K31/4245 ; A61K31/427 ; A61K31/428 ; A61K31/4433 ; A61K31/4439 ; A61K31/453 ; A61K31/4725 ; A61K31/5377 ; C07D207/06 ; C07D319/16 ; C07D405/10 ; C07D405/14 ; C07D319/18 ; C07D405/06 ; C07D409/14 ; C07D413/14
Abstract:
A method of treating a glomerular disease selected from the group consisting of mesangial proliferative glomerulonephritis, collapsing glomerulopathy, proliferative lupus nephritis, crescentic glomerulonephritis and membranous nephropathy in a subject comprises administering to the subject an effective amount of a glucosylceramide synthase inhibitor.
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