An actuator assembly for effective interventionless activation of a valve in wells of multilateral architecture. The assembly may be pressure actuated from an oilfield surface even in certain circumstances where another valve in another leg of the well has been opened in a manner compromising pressure control of the well. Due to the multi-stage nature of the actuator, pressure based activation remains viable as a result of supplemental and/or fail-safe modes of actuation, for example, where such pressure control becomes compromised.