Invention Grant
US09482669B2 Crystal structure of the NanR and ManNAc-6P complex, and uses thereof
有权
NanR和ManNAc-6P复合物的晶体结构及其用途
- Patent Title: Crystal structure of the NanR and ManNAc-6P complex, and uses thereof
- Patent Title (中): NanR和ManNAc-6P复合物的晶体结构及其用途
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Application No.: US14310879Application Date: 2014-06-20
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Publication No.: US09482669B2Publication Date: 2016-11-01
- Inventor: Sang Ho Choi , Byoung Sik Kim , Myung Hee Kim , Jung Won Hwang
- Applicant: SNU R&DB FOUNDATION , KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
- Applicant Address: KR Seoul KR Daejeon
- Assignee: SNU R&DB FOUNDATION,KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
- Current Assignee: SNU R&DB FOUNDATION,KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
- Current Assignee Address: KR Seoul KR Daejeon
- Agency: Gavrilovich, Dodd & Lindsey LLP
- Agent Joseph R. Baker, Jr
- Priority: KR10-2013-0071369 20130621
- Main IPC: G01N33/569
- IPC: G01N33/569 ; C07K14/28
Abstract:
The present invention relates to a three-dimensional structure of a complex explored by crystallization of the complex of NanR which is a key pathogenic regulatory protein of Vibrio vulnificus and ManNA6P which is a NanR regulator. Further, the present invention relates to a modified NanR protein, a polynucleotide encoding the protein, a vector including the polynucleotide, and a transformant including the vector. Furthermore, the present invention relates to a method for screening a substance regulating interaction between NanR and the transcriptional control region of nan operon which is a gene cluster regulated by NanR, or a substance regulating interaction between NanR and ManNAc-6P, by designing three-dimensional structure of the complex, and to an antibacterial composition including the screened substance.
Public/Granted literature
- US20150010915A1 CRYSTAL STRUCTURE OF THE NanR AND ManNAc-6P COMPLEX, AND USES THEREOF Public/Granted day:2015-01-08
Information query
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