A method for segmenting a target image includes receiving the target image of an anatomical structure, registering a plurality of atlases to the target image, each of the atlases including an image and a plurality of labels corresponding to portions of the image, selecting a plurality of registered atlases, transferring the labels of selected registered atlases to the target image, combining the labels that are transferred to the target image using a fusion of a discriminative model and a generative model, and outputting a segmentation of the target image isolating the anatomical structure, wherein a segmentation of the target image is displayed.