A container including a reusable electronic seal, as well as a system and method for using the electronic seal are described. The container includes a closure member configured to detachably affix to a portion of the container, thereby sealing the container. In response to the closure member sealing the container, a signal generating component generates an electronic signal and transmits the electronic signal to a processing circuit operably connected to the signal generating component. The processing circuit includes a processing device configured to generate a unique code when the closure member is manipulated to open or close the container and an output device operably connected to the processing device and configured to output the unique code. The unique code is updated each time the container is opened, thereby providing a recipient with a way to determine whether the container has been opened during delivery.