Systems and methods for dynamic data masking are disclosed. The disclosed methods and systems can be used to dynamically mask data in cryptographic operations, such as advanced encryption standard (AES) operations, data encryption standard (DES) operations or triple DES operations. Specifically, data in cryptographic operations can be covered with unlimited and continuously changing masks. As an example, the Substitution table, key schedule, and state register in AES, or key schedule and selection functions in a DES or triple DES can be covered with unlimited and constantly changing masks. In an aspect, dynamic masking operations can be combined with orbital RAM algorithm and no-operation clocks to make power signature analysis in cryptographic attacks even more difficult.