A system and method can support data interoperability in a distributed data grid. The system can provide an acceptor in the distributed data grid, wherein the acceptor is associated with a cache that is based on the distributed data grid. Furthermore, the acceptor can receive incoming data from a first client, which can be a non-native client that is associated with a client application. Additionally, the system allows a second client, which can be a native client associated with the distributed cache, to share the received incoming data with the first client.