A lockout system that includes a lock portion and a key portion that removably cooperate with one another to allow selective interference with a throw lever associated with operation of an electrical panel. The lock portion and key portion each include a guide arrangement and an electrical interface that cooperate with one another. The guide arrangements cooperate with one another to align the electrical interfaces of the respective key and lock portions. The lock portion includes a movable lock arm that selectively interferes with motion of the throw lever. The position of the lock arm relative to the throw lever can be manipulated when the electrical interfaces of the key portion and the lock portion are engaged with one another. Preferably, the lock and key interface includes an RFID protocol associated with authorizing respective key portions to communicate with respective lock portions.