Invention Grant
US09523678B2 Fluorescent dyes with phosphorylated hydroxymethyl groups and their use in light microscopy and imaging techniques
有权
具有磷酸化羟甲基的荧光染料及其在光学显微镜和成像技术中的应用
- Patent Title: Fluorescent dyes with phosphorylated hydroxymethyl groups and their use in light microscopy and imaging techniques
- Patent Title (中): 具有磷酸化羟甲基的荧光染料及其在光学显微镜和成像技术中的应用
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Application No.: US14829169Application Date: 2015-08-18
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Publication No.: US09523678B2Publication Date: 2016-12-20
- Inventor: Stefan W. Hell , Shamil Nizamov , Gerald Donnert , Kirill Kolmakov , Heiko Schill , Lars Kastrup , Christian A. Wurm , Vladimir N. Belov , Johanna Wildanger , Katrin Willig
- Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
- Applicant Address: DE Munich
- Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
- Current Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
- Current Assignee Address: DE Munich
- Agency: Caesar Rivise, PC
- Main IPC: C09B57/02
- IPC: C09B57/02 ; G01N33/52 ; C09B11/24 ; C09B57/10 ; G01N33/58 ; G01N33/533
Abstract:
The invention relates to novel fluorescent dyes with phosphorylated hydroxymethyl groups, a method for preparing the same as well as to their use in imaging techniques. The fluorescent dyes are coumarin, rhodamine or BODIPY dyes having of one of the following general formulae I-III: wherein W=OP(O)Y1Y2 or P(O)Y1Y2, where Y1 and Y2 independently denote any of the following residues: OH, O(−), ORa and ORb, NHRa and NHRb, NRaRb and NRcRd, ORa and NHRb, ORa and NRbRc, NHRa and NRbRc; and any salt thereof.
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