Invention Grant
US09523680B2 Global Proteomic screening of random bead arrays using mass spectrometry imaging
有权
使用质谱成像的随机珠阵列的全球蛋白质组学筛选
- Patent Title: Global Proteomic screening of random bead arrays using mass spectrometry imaging
- Patent Title (中): 使用质谱成像的随机珠阵列的全球蛋白质组学筛选
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Application No.: US13172164Application Date: 2011-06-29
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Publication No.: US09523680B2Publication Date: 2016-12-20
- Inventor: Mark J. Lim , Vladislav B. Bergo , Kenneth J. Rothschild
- Applicant: Mark J. Lim , Kenneth J. Rothschild
- Applicant Address: US MA Watertown
- Assignee: AmberGen, Inc.
- Current Assignee: AmberGen, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Medlen & Carroll, LLP
- Main IPC: G01N33/543
- IPC: G01N33/543 ; G01N33/68
Abstract:
Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
Public/Granted literature
- US20120077688A1 Global Proteomic Screening Of Random Bead Arrays Using Mass Spectrometry Imaging Public/Granted day:2012-03-29
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