Invention Grant
US09523691B2 Use of the olfactomedin-4 protein (OLFM4) in colorectal cancer diagnosis
有权
嗅觉蛋白-4蛋白（OLFM4）在结肠直肠癌诊断中的应用
- Patent Title: Use of the olfactomedin-4 protein (OLFM4) in colorectal cancer diagnosis
- Patent Title (中): 嗅觉蛋白-4蛋白（OLFM4）在结肠直肠癌诊断中的应用
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Application No.: US14002225Application Date: 2011-03-02
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Publication No.: US09523691B2Publication Date: 2016-12-20
- Inventor: Catherine Guette , Olivier Coqueret , Benjamin Barre , Erick Gamelin
- Applicant: Catherine Guette , Olivier Coqueret , Benjamin Barre , Erick Gamelin
- Applicant Address: FR Angers
- Assignee: INSTITUT DE CANCEROLOGIE DE L'OUEST
- Current Assignee: INSTITUT DE CANCEROLOGIE DE L'OUEST
- Current Assignee Address: FR Angers
- Agency: Foley & Lardner LLP
- International Application: PCT/IB2011/000787 WO 20110302
- International Announcement: WO2012/117267 WO 20120907
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/574 ; A61K31/4745 ; A61K31/513 ; A61K31/519 ; A61K33/24 ; A61K39/395 ; A61K45/06 ; C12Q1/68 ; A61K31/555 ; G01N1/28
Abstract:
The present invention provides a method for diagnosing KRAS mutations in colorectal cancers by measuring the level of OLFM4. In another aspect, the present invention relates a method of predicting the responds to a chemotherapeutic agent of a subject suffering from a colorectal cancer: according to the present invention, the by determining the OLFM4 levels. According to the present invention, the response can be predicted by determining the OLFM4 levels. This result in turn permits the design or the adaptation of a treatment of the said subject with the said chemotherapeutic agent.
Public/Granted literature
- US20130336969A1 USE OF OLFACTOMEDIN-4 PROTEIN (OLFM4) IN COLORECTAL CANCER DIAGNOSIS Public/Granted day:2013-12-19
Information query
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