Methods and structure for host-side device drivers for Redundant Array of Independent Disks (RAID) systems. One system includes a processor and memory of a host, which implement a device driver. The device driver receives an Input/Output (I/O) request from an Operating System (OS) of the host, translates Logical Block Addresses (LBAs) from the received request into physical addresses at multiple storage devices, generates child I/O requests directed to the physical addresses based on the received request, and accesses an address lock system at a RAID controller to determine whether the physical addresses are accessible. If the physical addresses are accessible, the device driver reserves the physical addresses by updating the address lock system, and directs the child I/O requests to a hardware path at the RAID controller for handling single-strip I/O requests. If the physical addresses are not accessible, the device driver delays processing of the child I/O requests.