Invention Grant
US09532554B2 Method for inducing hepatocellular variation, and production method for chimeric non-human animal having humanized liver
有权
诱导肝细胞变异的方法，以及具有人源化肝脏的嵌合非人动物的制备方法
- Patent Title: Method for inducing hepatocellular variation, and production method for chimeric non-human animal having humanized liver
- Patent Title (中): 诱导肝细胞变异的方法，以及具有人源化肝脏的嵌合非人动物的制备方法
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Application No.: US14348196Application Date: 2012-09-28
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Publication No.: US09532554B2Publication Date: 2017-01-03
- Inventor: Hideki Taniguchi , Yun-Wen Zheng
- Applicant: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY
- Applicant Address: JP Yokohama-Shi, Kanawaga
- Assignee: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY
- Current Assignee: PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY
- Current Assignee Address: JP Yokohama-Shi, Kanawaga
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2011-215977 20110930
- International Application: PCT/JP2012/075019 WO 20120928
- International Announcement: WO2013/047720 WO 20130404
- Main IPC: A01K67/027
- IPC: A01K67/027 ; C12N15/00 ; G01N33/00 ; C12N5/071 ; G01N33/50
Abstract:
The present invention provides (1) a method for producing a non-human animal having a humanized liver, comprising transplanting human hepatic stem cells and/or hepatic progenitor cells and/or immature hepatocytes to a liver-damaged non-human animal to induce the differentiation of the cells into hepatocytes, (2) a non-human animal having a humanized liver, produced by the method, (3) a method for examining the pharmacokinetics and/or hepatotoxicity of a test substance, comprising using the animal, (4) a method for producing human hepatocytes, comprising transplanting human hepatic stem cells and/or hepatic progenitor cells and/or immature hepatocytes to a liver-damaged non-human animal to induce the differentiation of the cells into hepatocytes, and (5) a method for examining the pharmacokinetics and/or hepatotoxicity of a test substance, comprising using human hepatocytes produced by the method.
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