Invention Grant
- Patent Title: Inhibition of human immunodeficiency virus integrase reaching dimer formation utilizing single-chain variable antibodies
- Patent Title (中): 使用单链可变抗体抑制人类免疫缺陷病毒整合酶达到二聚体形成
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Application No.: US13923494Application Date: 2013-06-21
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Publication No.: US09533040B2Publication Date: 2017-01-03
- Inventor: Anna Marie Skalka , Mark Andrake , Ravi Shankar Bojja
- Applicant: Institute for Cancer Research
- Applicant Address: US PA Philadelphia
- Assignee: Institute for Cancer Research
- Current Assignee: Institute for Cancer Research
- Current Assignee Address: US PA Philadelphia
- Agency: Stradley Ronon Stevens & Young, LLP
- Main IPC: C12Q1/34
- IPC: C12Q1/34 ; C07K16/10 ; A61K39/395 ; C12Q1/18 ; C12N9/22
Abstract:
Methods to inhibit the formation of retrovirus integrase reaching dimers, to dissociate retrovirus integrase reaching dimers, and to stabilize retrovirus integrase reaching dimers in a conformation in which retrovirus DNA-to host cell DNA integration activity of the integrase is inhibited are provided. Methods for treating a retrovirus infection, which target retrovirus integrase reaching dimer formation and/or stability are also provided.
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