A clamping device for a sprayer can is provided, including a shell body. The shell body includes a grip portion and a clamping portion for clamping one end of a sprayer can. The sprayer can is provided with a dispenser valve. The clamping portion includes a circumferential wall, and the circumferential wall defines a space for receiving the dispenser valve and a receiving opening communicating with the space. The circumferential wall is further formed with a window which communicates with the space, and the dispenser valve can spray through the window. The circumferential wall includes first flexible portions and at least one second flexible portion. At least one said second flexible portion is connected between every two adjacent first flexible portions. The second flexible portion is greater than the first flexible portion in flexibility.