Invention Grant
- Patent Title: Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates
- Patent Title (中): 用于酶及其共轭物的超敏感化学发光底物
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Application No.: US14459494Application Date: 2014-08-14
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Publication No.: US09533974B2Publication Date: 2017-01-03
- Inventor: Brij Pal Giri , Dinesh J. Dagli , Pritam Singh
- Applicant: Michigan Diagnostics, LLC
- Applicant Address: US MI Royal Oak
- Assignee: Michigan Diagnostics, LLC
- Current Assignee: Michigan Diagnostics, LLC
- Current Assignee Address: US MI Royal Oak
- Agency: The Weintraub Group, P.L.C.
- Main IPC: G01N33/533
- IPC: G01N33/533 ; C07D405/12 ; C09B15/00 ; C12Q1/00 ; G01N33/531 ; G01N21/76 ; C07H15/24 ; C07H15/26

Abstract:
New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are water-soluble acridanes, enhancer coupled acridanes, bis and tris-acridanes as well as acridane-1,2-dioxetanes. Among the new 1,2-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The 1,2-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent, an aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP.
Public/Granted literature
- US20150031889A1 ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES Public/Granted day:2015-01-29
Information query
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