Invention Grant
US09533982B2 Substituted bicyclic heteroaryl carboxamide analogs as mGluR5 negative allosteric modulators
有权
取代的双环杂芳基羧酰胺类似物作为mGluR5负变构调节剂
- Patent Title: Substituted bicyclic heteroaryl carboxamide analogs as mGluR5 negative allosteric modulators
- Patent Title (中): 取代的双环杂芳基羧酰胺类似物作为mGluR5负变构调节剂
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Application No.: US14664792Application Date: 2015-03-20
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Publication No.: US09533982B2Publication Date: 2017-01-03
- Inventor: P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Andrew S. Felts
- Applicant: Vanderbilt University
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Ballard Spahr LLP
- Main IPC: C07D401/14
- IPC: C07D401/14 ; A61K31/506 ; C07D417/14 ; C07D403/14
Abstract:
Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Public/Granted literature
- US20150266866A1 Substituted Bicyclic Heteroaryl Carboxamide Analogs As Mglur5 Negative Allosteric Modulators Public/Granted day:2015-09-24
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