Invention Grant
US09534014B2 Pharmaceutical compositions with attenuated release of phenolic opioids
有权
具有减轻酚类阿片样物质释放的药物组合物
- Patent Title: Pharmaceutical compositions with attenuated release of phenolic opioids
- Patent Title (中): 具有减轻酚类阿片样物质释放的药物组合物
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Application No.: US14320351Application Date: 2014-06-30
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Publication No.: US09534014B2Publication Date: 2017-01-03
- Inventor: Thomas E. Jenkins , Julie D. Seroogy , Jonathan W. Wray
- Applicant: Signature Therapeutics, Inc.
- Applicant Address: US CA Palo Alto
- Assignee: Signature Therapeutics, Inc.
- Current Assignee: Signature Therapeutics, Inc.
- Current Assignee Address: US CA Palo Alto
- Agency: Bozicevic, Field & Francis LLP
- Agent Khin K. Chin; Carol L. Francis
- Main IPC: A61K31/497
- IPC: A61K31/497 ; C07K5/072 ; A61K31/155 ; A61K31/485 ; A61K31/135 ; A61K31/195 ; A61K31/439 ; A61K31/445 ; A61K31/451 ; A61K31/495 ; A61K31/55 ; A61K38/05 ; C07C215/64 ; C07C257/18 ; C07C279/18 ; C07D211/66 ; C07D217/04 ; C07D221/26 ; C07D223/04 ; C07D295/185 ; C07D491/08 ; A61K47/48
Abstract:
Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenolic opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the prodrug so as to attenuate enzymatic cleavage of the prodrug.
Public/Granted literature
- US20150031635A1 Pharmaceutical Compositions with Attenuated Release of Phenolic Opioids Public/Granted day:2015-01-29
Information query
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