Invention Grant
US09534020B2 Immunogenic polypeptides comprising a modified loop peptide presenting the HIV-1 GP120 3074 mAb epitope and scaffold proteins containing said peptide
有权
包含呈递HIV-1 GP120 3074mAb表位的修饰环肽和含有所述肽的支架蛋白的免疫原性多肽
- Patent Title: Immunogenic polypeptides comprising a modified loop peptide presenting the HIV-1 GP120 3074 mAb epitope and scaffold proteins containing said peptide
- Patent Title (中): 包含呈递HIV-1 GP120 3074mAb表位的修饰环肽和含有所述肽的支架蛋白的免疫原性多肽
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Application No.: US13876918Application Date: 2011-09-28
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Publication No.: US09534020B2Publication Date: 2017-01-03
- Inventor: Timothy Cardozo , Xiang-peng Kong , Susan Zolla-Pazner , Shan Lu , Shixia Wang , Maxim Totrov
- Applicant: Timothy Cardozo , Xiang-peng Kong , Susan Zolla-Pazner , Shan Lu , Shixia Wang , Maxim Totrov
- Applicant Address: US NY New York US MA Boston US CA San Diego
- Assignee: New York University,University of Massachusetts,Molsoft LLC
- Current Assignee: New York University,University of Massachusetts,Molsoft LLC
- Current Assignee Address: US NY New York US MA Boston US CA San Diego
- Agency: LeClairRyan, a Professional Corporation
- International Application: PCT/US2011/053686 WO 20110928
- International Announcement: WO2012/050893 WO 20120419
- Main IPC: C07K14/005
- IPC: C07K14/005 ; C07K7/08 ; A61K39/21 ; C07K14/00 ; C07K14/245 ; C07K14/28 ; A61K39/12 ; A61K39/00
Abstract:
The present invention is directed to a recombinant immunogenic polypeptide. The polypeptide includes a loop peptide inserted into an immunogenic scaffold protein. The loop polypeptide has an amino acid sequence which presents the 3074 mAb- or the 2219/2557 mAb-targeted epitope of the HIV gp120 protein and not other known epitopes of the HIV gp120 protein. When used as an immunogen, the polypeptide induces an antibody response which neutralizes heterologous HIV-1 viruses in a pattern similar to that observed for the 3074 mAb- or the 2219/2557 mAb-targeted epitope, respectively. Pharmaceutical compositions containing the immunogenic polypeptide as well as methods of making and using it are also disclosed.
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