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US09534233B2 Nucleic acid construct and use of the same 有权
核酸构建与使用相同

Nucleic acid construct and use of the same
Abstract:
The present invention is related to a nucleic acid construct comprising an expression unit for the expression of E1B, wherein the expression unit comprises a promoter, a nucleotide sequence coding for E1B, and a 3′UTR, wherein the promoter is operatively linked to the nucleotide sequence coding for E1B, wherein the 3′UTR comprises 30 or less than 30 Exonic Enhancer Elements (ESEs), preferably 20 or less than 20 Exonic Enhancer Elements (ESEs), and wherein the 3′ UTR is a non-viral 3′ UTR.
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