Invention Grant
US09535060B2 Adrenomedullin assays and methods for determining mature adrenomedullin
有权
肾上腺髓质素测定法和确定成熟肾上腺髓质素的方法
- Patent Title: Adrenomedullin assays and methods for determining mature adrenomedullin
- Patent Title (中): 肾上腺髓质素测定法和确定成熟肾上腺髓质素的方法
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Application No.: US14358147Application Date: 2012-11-16
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Publication No.: US09535060B2Publication Date: 2017-01-03
- Inventor: Andreas Bergmann
- Applicant: SPHINGOTEC GMBH
- Applicant Address: DE Hennigsdorf
- Assignee: SPHINGOTEC GMBH
- Current Assignee: SPHINGOTEC GMBH
- Current Assignee Address: DE Hennigsdorf
- Agency: Millen, White, Zelano, Branigan, P.C.
- Priority: EP11189447 20111116; EP11189448 20111116; EP11189449 20111116; EP11189450 20111116; EP11189452 20111116; EP12160014 20120316; EP12160015 20120316; EP12160016 20120316; EP12160017 20120316; EP12160018 20120316; EP12186449 20120927
- International Application: PCT/EP2012/072928 WO 20121116
- International Announcement: WO2013/072509 WO 20130523
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/543 ; C07K16/26 ; G01N33/68 ; A61K31/137 ; A61K38/17 ; A61K39/395 ; A61K45/06 ; C07K16/18 ; A61K39/00
Abstract:
Subject of the present invention is an in vitro method for therapy follow-up in septic patients wherein the concentration of mature ADM 1-52 and/or mature ADM 1-52-Gly in a sample of bodily fluid of said septic patient is determined using an assay comprising two binders that bind to two different regions within the region of mature adrenomedullin and/or adrenomedullin-Gly that is aminoacid 21-52-amid SEQ ID No. 1 or aminoacid 21-52-Gly SEQ ID No. 2 wherein each of said regions comprises at least 4 or 5 amino acids.Subject of the present invention are further assays and calibration methods.
Public/Granted literature
- US20140322824A1 ADRENOMEDULLIN ASSAYS AND METHODS FOR DETERMINING MATURE ADRENOMEDULLIN Public/Granted day:2014-10-30
Information query
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