An integrated circuit and method for establishing scan test architecture in the integrated circuit is provided. The integrated circuit includes a plurality of circuit modules. Each circuit module includes a clock control unit, a first pipeline unit, a serialized compressed scan circuit and a second pipeline unit. The clock control unit generates a scan clock according to a test clock. The first pipeline unit converts a test input signal into first data according to the scan clock. The serialized compressed scan circuit generates second data according to the first data and the test clock. The second pipeline unit converts the second data into a test output signal according to the scan clock. The scan clock of each of the circuit modules is independent from the scan clocks of the other circuit modules, thereby reducing the difficulty and cost of timing analysis and adjustment.