Invention Grant
- Patent Title: NMR quantification of TMAO
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Application No.: US13801604Application Date: 2013-03-13
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Publication No.: US09535144B2Publication Date: 2017-01-03
- Inventor: James D. Otvos , Elias J. Jeyarajah , Justyna E. Wolak-Dinsmore , Thomas M. O'Connell , Dennis W. Bennett , Stanley L. Hazan
- Applicant: LipoScience Inc.
- Applicant Address: US NC Raleigh
- Assignee: LIPOSCIENCE, INC.
- Current Assignee: LIPOSCIENCE, INC.
- Current Assignee Address: US NC Raleigh
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: G01N33/48
- IPC: G01N33/48 ; G01N33/50 ; G01R33/465 ; G01N33/66 ; G06F19/12 ; G06F19/26 ; G01N24/08
Abstract:
A defined peak region residing between about 3.2 and 3.4 ppm of a proton NMR spectrum of an in vitro biosample is electronically evaluated to determine a level of trimethylamine-N-oxide (“TMAO”). The biosamples may be any suitable biosamples including human serum with a normal biologic range of between about 1-50 μM or urine with a normal biologic range of between about 0-1000 μM.
Public/Granted literature
- US20130325353A1 NMR QUANTIFICATION OF TMAO Public/Granted day:2013-12-05
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