A method of controlling energy consumption in a building. The method includes receiving occupant request data including a plurality of requests, wherein each of the plurality of requests corresponds to one of a plurality of zones in the building wherein the occupant request data is received via a cloud computing resource. The method also includes receiving weather data including at least one of current weather measurement data and weather forecast data wherein the weather data is received via a cloud computing resource. In addition, a facility management rule is received via a cloud computing resource. Further, the method includes generating a plurality of output control signals via cloud computing resource, wherein each of the plurality of output control signals is based on one of a plurality of requests and predicted occupant schedules, energy price data and the facility management rule. The control signals are generated by using simulation-based model predictive control method to determine a set of optimized control signals based on optimized energy use or optimized energy cost. The optimized control signals are transmitted to controllers.