Systems and techniques are disclosed for dynamically and automatically selecting an appropriate compression technique and/or compression parameters for digital images in order to reduce or prevent loss of significant information that may negatively impact the utility or usefulness of the digital images. For example, based on various image characteristics associated with a digital image, the system may dynamically compress the image using particular compression techniques and/or by adjusting compression parameters, to maintain significant information of the image. The system may select compression techniques and/or compression parameters based on one or more compression rules, which may be associated with image characteristics patient characteristics, medical history, etc. Further, the system may, based on the one or more compression rules, compress the image to a maximum degree of compression while maintaining the significant information of the image.