Disclosed are systems and methods for enabling secure execution of code in hypervisor mode. An exemplary method comprises: loading a hypervisor configured to check integrity of protected virtual memory pages; loading a trusted program configured to make hypercalls to the hypervisor; making by the trusted program a first hypercall to the hypervisor; responsive to the first hypercall, generating by the hypervisor a token, which is used by the hypervisor to identify the trusted program during subsequent hypercalls; allocating a memory page for storing the token and a memory address of the hypervisor; and returning the allocated memory page address to the trusted program.