A method and a base station for calibrating data transmitted by coordinated APs are disclosed. The method includes: a base station obtaining an uplink channel frequency-domain response and a downlink channel frequency-domain response between a first AP and a second AP which participate in coordination; the base station dividing the uplink channel frequency-domain response by the downlink channel frequency-domain response to obtain an uplink and downlink channel response difference between the first AP and the second AP; and the base station calibrating the data transmitted by the first AP and the second AP in coordination according to the uplink and downlink channel response difference. The method and base station in the embodiments of the present document are applied to calibrate the data transmitted by coordinated APs.