Invention Grant
- Patent Title: Induction of mucosal tolerance to antigens
- Patent Title (中): 诱导对抗原的粘膜耐受
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Application No.: US14216887Application Date: 2014-03-17
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Publication No.: US09539291B2Publication Date: 2017-01-10
- Inventor: Pieter Rottiers , Veerle Snoeck
- Applicant: INTREXON ACTOBIOTICS NV
- Applicant Address: BE Zwijnaarde
- Assignee: INTREXON ACTOBIOTICS NV
- Current Assignee: INTREXON ACTOBIOTICS NV
- Current Assignee Address: BE Zwijnaarde
- Agency: Drinker Biddle & Reath LLP
- Priority: EP05111467 20051129
- Main IPC: A61K35/74
- IPC: A61K35/74 ; A61K35/747 ; A61K38/20 ; A61K39/00 ; A61K39/39 ; A61K39/35 ; A61K39/395 ; A61K36/064
Abstract:
The present invention relates to the induction of tolerance to antigens, by mucosal, preferably oral delivery of the antigen in combination with an immunomodulating compound producing micro-organism. More specifically, the invention relates to the induction of Foxp3+ and/or IL-10 and/or TGF-β producing regulatory T-cells, capable of suppressing undesired immune responses toward an antigen, by oral delivery of said antigen in combination with an immunosuppressing cytokine secreting micro-organism.
Public/Granted literature
- US20140322266A1 INDUCTION OF MUCOSAL TOLERANCE TO ANTIGENS Public/Granted day:2014-10-30
Information query
