Invention Grant
- Patent Title: Recombinant bacterium and uses thereof
- Patent Title (中): 重组细菌及其用途
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Application No.: US14516090Application Date: 2014-10-16
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Publication No.: US09539313B2Publication Date: 2017-01-10
- Inventor: Subash Sad , Lakshmi Krishnan , Fanny Tzelepis , Valeria Alcon , Kevin G. Young
- Applicant: National Research Council of Canada
- Applicant Address: CA Ottawa
- Assignee: National Research Council of Canada
- Current Assignee: National Research Council of Canada
- Current Assignee Address: CA Ottawa
- Agency: Cermak Nakajima & McGowan LLP
- Agent Shelly Guest Cermak
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/12 ; C07K14/195 ; C07K14/47 ; C07K14/705 ; C07K14/71 ; C07K14/77 ; C12N1/20 ; C12N9/36 ; C12N9/64 ; C12N9/02
Abstract:
The present invention relates to a recombinant bacterium expressing an antigen that is translocated to the cytosol of a host organism, and uses thereof. To this end, the present invention provides a recombinant bacterium comprising a nucleic acid encoding an antigen that is translocated to the cytosol of a host cell utilizing Type III secretion system. The recombinant bacterium is generally chosen from intracellular pathogens that reside in the phagosome and fail to induce rapid T cell activation. The translocated antigen may be a viral antigen, a bacterial antigen, or a tumor antigen. Methods of imparting immunity using the recombinant bacterium are also provided.
Public/Granted literature
- US20150140028A1 Recombinant Bacterium and Uses Thereof Public/Granted day:2015-05-21
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