Invention Grant
US09539322B2 Method of enhancing an antitumor T cell response by administering an anti-IL-6 receptor antibody
有权
通过施用抗IL-6受体抗体来增强抗肿瘤T细胞应答的方法
- Patent Title: Method of enhancing an antitumor T cell response by administering an anti-IL-6 receptor antibody
- Patent Title (中): 通过施用抗IL-6受体抗体来增强抗肿瘤T细胞应答的方法
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Application No.: US13700355Application Date: 2011-05-27
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Publication No.: US09539322B2Publication Date: 2017-01-10
- Inventor: Takashi Nishimura
- Applicant: Takashi Nishimura
- Applicant Address: JP Hokkaido JP Tokyo
- Assignee: National University Corporation Hokkaido University,Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: National University Corporation Hokkaido University,Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Hokkaido JP Tokyo
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Priority: JP2010-122951 20100528
- International Application: PCT/JP2011/062209 WO 20110527
- International Announcement: WO2011/149051 WO 20111201
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K31/7068 ; C07K16/28 ; A61K45/06
Abstract:
An objective of the present invention is to provide novel therapeutic agents for cancer, which have an excellent antitumor effect in cancer patients by enhancing their immune function. The present inventors discovered that the administration of at IL-6 inhibitor and/or gemcitabine or a salt thereof to tumor-bearing organisms yields an excellent antitumor T cell response-enhancing effect, and completed the present invention. In addition, the present inventors discovered that the T cell response-enhancing effect produces an excellent antitumor effect.
Public/Granted literature
- US20130202588A1 Antitumor T Cell Response Enhancer Public/Granted day:2013-08-08
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