Invention Grant
US09540356B2 Compounds having a protective activity against toxins with intracellular activity
有权
对具有细胞内活性的毒素具有保护活性的化合物
- Patent Title: Compounds having a protective activity against toxins with intracellular activity
- Patent Title (中): 对具有细胞内活性的毒素具有保护活性的化合物
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Application No.: US14436737Application Date: 2013-10-18
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Publication No.: US09540356B2Publication Date: 2017-01-10
- Inventor: Daniel Gillet , Julien Barbier , Ludger Johannes , Jean-Christophe Cintrat , Romain Noel
- Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , INSTITUT CURIE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Applicant Address: FR Paris FR Paris FR Paris
- Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES,INSTITUT CURIE,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Current Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES,INSTITUT CURIE,CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
- Current Assignee Address: FR Paris FR Paris FR Paris
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: EP12306297 20121019
- International Application: PCT/EP2013/071863 WO 20131018
- International Announcement: WO2014/060586 WO 20140424
- Main IPC: C07D409/04
- IPC: C07D409/04 ; C07D409/14 ; C07D239/91 ; C07D417/14
Abstract:
The present invention concerns a new family of 2,3-dihydroquinazolin-4(1H)-one compounds of general formula (I), and the use thereof as inhibitors of the toxic effects of toxins with intracellular activity, such as ricin or Shiga toxin, for example, using retrograde transport to intoxicate cells.
Public/Granted literature
- US20150291568A1 NEW COMPOUNDS HAVING A PROTECTIVE ACTIVITY AGAINST TOXINS WITH INTRACELLULAR ACTIVITY Public/Granted day:2015-10-15
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