Invention Grant
US09540359B2 Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity
有权
具有BACE1抑制活性的二氢恶嗪或氧氮杂衍生物
- Patent Title: Dihydrooxazine or oxazepine derivatives having BACE1 inhibitory activity
- Patent Title (中): 具有BACE1抑制活性的二氢恶嗪或氧氮杂衍生物
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Application No.: US14434013Application Date: 2013-10-23
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Publication No.: US09540359B2Publication Date: 2017-01-10
- Inventor: Ken-ichi Kusakabe , Syuhei Yoshida , Kenji Nakahara , Tsuyoshi Hasegawa , Genta Tadano , Kouki Fuchino
- Applicant: Shionogi & Co., Ltd.
- Applicant Address: JP Osaka
- Assignee: Shionogi & Co., Ltd.
- Current Assignee: Shionogi & Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Hamre, Schumann, Mueller & Larson, P.C.
- Priority: JP2012-234461 20121024; JP2013-154451 20130725
- International Application: PCT/JP2013/079472 WO 20131023
- International Announcement: WO2014/065434 WO 20140501
- Main IPC: C07D413/12
- IPC: C07D413/12 ; C07D498/04 ; C07D413/14 ; C07D498/10

Abstract:
The present invention provides a compound which has an effect of inhibiting amyloid β production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid β proteins.A compound of the formula (I): wherein X is —C(R3a)(R3b)—, —C(R3a)(R3b)—C(R3c)(R3d)— or —C(R3a)═C(R3c)—, R1 is substituted or unsubstituted alkyl or the like, R2a, R2b, R3a, R3b, R3c and R3d are each independently hydrogen, halogen or the like, R4 is hydrogen or halogen, Ring B is substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle, or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20150266865A1 DIHYDROOXAZINE OR OXAZEPINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY Public/Granted day:2015-09-24
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