Invention Grant
- Patent Title: Benzimidazole tetrahydrofuran derivatives
- Patent Title (中): 苯并咪唑四氢呋喃衍生物
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Application No.: US14420024Application Date: 2013-08-15
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Publication No.: US09540364B2Publication Date: 2017-01-10
- Inventor: James M. Apgar , Tesfaye Biftu , Ping Chen , Danqing Feng , Jacqueline D. Hicks , Ahmet Kekec , Kenneth J. Leavitt , Bing Li , Iyassu Sebhat , Xiaoxia Qian , Lan Wei , Robert R. Wilkening , Zhicai Wu
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Baerbel R. Brown; Catherine D. Fitch
- International Application: PCT/US2013/055166 WO 20130815
- International Announcement: WO2014/031441 WO 20140227
- Main IPC: C07D405/12
- IPC: C07D405/12 ; C07D405/14 ; C07D413/14 ; C07D417/14 ; A61K31/366 ; A61K31/397 ; A61K31/4184 ; A61K31/4192 ; A61K31/4196 ; A61K31/427 ; A61K31/4985 ; A61K31/506 ; A61K31/5377
Abstract:
Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
Public/Granted literature
- US20150218149A1 NOVEL BENZIMIDAZOLE TETRAHYDROFURAN DERIVATIVES Public/Granted day:2015-08-06
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