Invention Grant
- Patent Title: Ring-fused heterocyclic compound
- Patent Title (中): 环稠合杂环化合物
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Application No.: US14418253Application Date: 2013-07-31
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Publication No.: US09540366B2Publication Date: 2017-01-10
- Inventor: Takayuki Furuta , Takashi Sawada , Tomohiro Danjo , Takahiro Nakajima , Noriaki Uesaka
- Applicant: Kyowa Hakko Kirin Co., Ltd.
- Applicant Address: JP Tokyo
- Assignee: Kyowa Hakko Kirin Co., Ltd.
- Current Assignee: Kyowa Hakko Kirin Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent David G. Conlin; Joohee Lee
- Priority: JP2012-169480 20120731
- International Application: PCT/JP2013/070755 WO 20130731
- International Announcement: WO2014/021383 WO 20140206
- Main IPC: C07D471/02
- IPC: C07D471/02 ; C07D491/02 ; C07D498/02 ; C07D513/02 ; C07D515/02 ; A61K31/44 ; C07D471/04 ; A61K31/437 ; A61K31/444 ; A61K31/4545 ; A61K31/5377

Abstract:
The ring-fused heterocyclic compound or a pharmaceutically acceptable salt thereof according to the present invention has a T-type calcium channel regulatory effect, and is useful, for example, as a medicament for treating and/or preventing pruritus. The present invention provides a ring-fused heterocyclic compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof and the like which has a T-type calcium channel regulatory effect and is useful as a therapeutic and/or preventive agent for pruritus, and the like. [wherein, R1 represents optionally substituted lower alkyl and the like, R2 represents optionally substituted lower alkyl and the like, R3 represents the formula (II): (wherein, n represents 0 or 1, R3a represents a hydrogen atom and the like, R3b represents a hydrogen atom and the like, and R3c represents a hydrogen atom and the like) and the like, Q represents a hydrogen atom and the like, and W1 represents a nitrogen atom and the like, W2 represents a nitrogen atom and the like].
Public/Granted literature
- US20150284384A1 RING-FUSED HETEROCYCLIC COMPOUND Public/Granted day:2015-10-08
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