Invention Grant
US09540391B2 Isomannide derivatives as inhibitors of soluble epoxide hydrolase 有权
异烟肼衍生物作为可溶性环氧化物水解酶的抑制剂

Isomannide derivatives as inhibitors of soluble epoxide hydrolase
Abstract:
The present invention relates to compounds of the formula (I), wherein R1, R11, R12 and X have the meanings indicated in the claims. The compounds of formula I are valuable pharmacologically active compounds. They are highly potent and selective soluble epoxide hydrolase inhibitors and are suitable, for example, for the therapy and prophylaxis of renal failure, diabetic nephropathy, type 2 diabetes mellitus, inflammation or could show beneficial effects in pain, dyslipidemia and atherosclerosis. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
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