Invention Grant
US09540391B2 Isomannide derivatives as inhibitors of soluble epoxide hydrolase
有权
异烟肼衍生物作为可溶性环氧化物水解酶的抑制剂
- Patent Title: Isomannide derivatives as inhibitors of soluble epoxide hydrolase
- Patent Title (中): 异烟肼衍生物作为可溶性环氧化物水解酶的抑制剂
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Application No.: US14761270Application Date: 2014-01-16
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Publication No.: US09540391B2Publication Date: 2017-01-10
- Inventor: Katrin Lorenz , Kristin Breitschopf , Hartmut Strobel , Maria Mendez-Perez , Li-hsing Wang , Alexander Schiffer , Joseph T. Kim , Hans-Peter Nestler , Mark Drew
- Applicant: SANOFI
- Applicant Address: FR Paris
- Assignee: SANOFI
- Current Assignee: SANOFI
- Current Assignee Address: FR Paris
- Agency: Morrison & Foerster LLP
- Priority: EP13305051 20130117
- International Application: PCT/EP2014/050796 WO 20140116
- International Announcement: WO2014/111465 WO 20140724
- Main IPC: C07D493/04
- IPC: C07D493/04 ; C07D519/00

Abstract:
The present invention relates to compounds of the formula (I), wherein R1, R11, R12 and X have the meanings indicated in the claims. The compounds of formula I are valuable pharmacologically active compounds. They are highly potent and selective soluble epoxide hydrolase inhibitors and are suitable, for example, for the therapy and prophylaxis of renal failure, diabetic nephropathy, type 2 diabetes mellitus, inflammation or could show beneficial effects in pain, dyslipidemia and atherosclerosis. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
Public/Granted literature
- US20150336979A1 ISOMANNIDE DERIVATIVES AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE Public/Granted day:2015-11-26
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