Invention Grant
- Patent Title: Inhibitors of the farnesoid X receptor and uses in medicine
- Patent Title (中): 法尼基X受体的抑制剂和药物中的应用
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Application No.: US14909263Application Date: 2014-08-01
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Publication No.: US09540415B2Publication Date: 2017-01-10
- Inventor: Frank J. Gonzalez , Changtao Jiang , Cen Xie , Andrew D. Patterson , Fei Li , James B. Mitchell
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services , The Penn State Research Foundation
- Applicant Address: US DC Washington US PA University Park
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services,The Penn State Research Foundation
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services,The Penn State Research Foundation
- Current Assignee Address: US DC Washington US PA University Park
- Agency: Leydig, Voit & Mayer, Ltd.
- International Application: PCT/US2014/049460 WO 20140801
- International Announcement: WO2015/017813 WO 20150205
- Main IPC: C07J9/00
- IPC: C07J9/00 ; C07J41/00
Abstract:
Disclosed are inhibitors of the farnesoid X receptor, for example of formula (I), wherein R1, R2, R4, X, Y, Z, m, and n are as defined herein, which are useful in treating or preventing obesity, type 2 diabetes/insulin resistance and non alcoholic fatty liver disease in a mammal in need thereof. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least Cone compound of the invention, a method of method of inhibiting a farnesoid X receptor in a mammal, and a method of treating or preventing obesity in a mammal.
Public/Granted literature
- US20160159851A1 INHIBITORS OF THE FARNESOID X RECEPTOR AND USES IN MEDICINE Public/Granted day:2016-06-09
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