Invention Grant
- Patent Title: Mitochondria targeting peptide
- Patent Title (中): 线粒体靶向肽
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Application No.: US14424762Application Date: 2013-08-30
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Publication No.: US09540421B2Publication Date: 2017-01-10
- Inventor: Young Mi Kim , Young Cheol Kang , Yong Hee Kim
- Applicant: UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
- Applicant Address: KR Yongin-si
- Assignee: UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
- Current Assignee: UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
- Current Assignee Address: KR Yongin-si
- Agency: Abel Law Group, LLP
- Agent Lei Guo
- Priority: KR10-2012-0096446 20120831
- International Application: PCT/KR2013/007809 WO 20130830
- International Announcement: WO2014/035179 WO 20140306
- Main IPC: C07K14/005
- IPC: C07K14/005 ; C07K14/825 ; C12N9/08 ; C12N9/02 ; C12N9/12 ; C12N9/00 ; C07K7/06 ; C07K7/08 ; A61K38/00

Abstract:
The present invention relates to a mitochondria targeting peptide, a fusion protein in which the peptide is bound to the carboxyl terminus of a protein transduction domain, a fusion protein in which the peptide is bound to the carboxyl terminus of a protein transduction domain and an antioxidant is bound to the carboxyl terminus of the peptide, an antioxidant composition and a composition for preventing or treating Parkinson's disease including the fusion protein in which the antioxidant is bound, a recombinant polynucleotide in which a polynucleotide coding a protein transduction domain, a polynucleotide coding the peptide, and a polynucleotide coding an antioxidant protein are sequentially bound, to an expression vector including the polynucleotide, and to a transformed host cell including the expression vector.The mitochondria targeting peptide according to the present invention targets mitochondria with high efficiency not only when the peptide exists alone but also when the peptide is bound to a protein transduction domain and/or to an antioxidant. Further, the peptide has a small size and is thus a very suitable targeting carrier. The peptide becomes processed when introduced into mitochondria, and thus stably delivers the drug carried by the peptide.
Public/Granted literature
- US20150361140A1 MITOCHONDRIAL TARGETING PEPTIDE Public/Granted day:2015-12-17
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