Invention Grant
US09540438B2 Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
有权
醛标记的免疫球蛋白多肽及其使用方法
- Patent Title: Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
- Patent Title (中): 醛标记的免疫球蛋白多肽及其使用方法
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Application No.: US13350676Application Date: 2012-01-13
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Publication No.: US09540438B2Publication Date: 2017-01-10
- Inventor: Robyn M. Barfield , Mark Alan Breidenbach , Gregory W. deHart , David Rabuka
- Applicant: Robyn M. Barfield , Mark Alan Breidenbach , Gregory W. deHart , David Rabuka
- Applicant Address: US CA Emeryville
- Assignee: Redwood Bioscience, Inc.
- Current Assignee: Redwood Bioscience, Inc.
- Current Assignee Address: US CA Emeryville
- Agency: Bozicevic, Field & Francis LLP
- Agent Carol L. Francis
- Main IPC: C07K16/46
- IPC: C07K16/46 ; A61K39/395 ; A61K39/44 ; A61K39/39 ; C07K16/18 ; C07K16/08 ; C07K16/28 ; A61K47/48 ; C07K1/107 ; C07K1/13
Abstract:
The present disclosure provides aldehyde-tagged immunoglobulin (Ig) polypeptides that can be converted by a formylglycine-generating enzyme to produce a 2-formylglycine (FGly)-modified Ig polypeptide. An FGly-modified Ig polypeptide can be covalently and site-specifically bound to a moiety of interest to provide an Ig conjugate. The disclosure also encompasses methods of production of such aldehyde-tagged Ig polypeptides, FGly-modified Ig polypeptides, and Ig conjugates, as well as methods of use of same.
Public/Granted literature
- US20120183566A1 Aldehyde-Tagged Immunoglobulin Polypeptides and Methods of Use Thereof Public/Granted day:2012-07-19
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