Invention Grant
US09540441B2 Polynucleotide encoding antibody to human IL-3 receptor alpha chain
有权
编码针对人IL-3受体α链的抗体的多核苷酸
- Patent Title: Polynucleotide encoding antibody to human IL-3 receptor alpha chain
- Patent Title (中): 编码针对人IL-3受体α链的抗体的多核苷酸
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Application No.: US15182891Application Date: 2016-06-15
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Publication No.: US09540441B2Publication Date: 2017-01-10
- Inventor: Tomonori Tawara , Shinichiro Takayanagi , Yoshimasa Inagaki
- Applicant: KYOWA HAKKO KIRIN CO., LTD
- Applicant Address: JP Tokyo
- Assignee: KYOWA HAKKO KIRIN CO., LTD
- Current Assignee: KYOWA HAKKO KIRIN CO., LTD
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- Main IPC: C12N5/10
- IPC: C12N5/10 ; C12N15/12 ; C12N15/63 ; C07K16/28 ; G01N33/574
Abstract:
The present invention provides an antibody to human IL-3Rα chain, which does not inhibit IL-3 signaling and binds to B domain of the human IL-3Rα chain but does not bind to C domain of the human IL-3Rα chain; a composition for preventing or treating a blood tumor in which a cell expressing IL-3Rα is found in bone marrow or peripheral blood of a subject, which comprises the antibody to human IL-3Rα as an active ingredient; and a method for treating a blood tumor in which a cell expressing IL-3Rα is found in bone marrow or peripheral blood, which comprises administering, to a subject, a composition comprising the IL-3Rα antibody as an active ingredient.
Public/Granted literature
- US20160280792A1 ANTIBODY TO HUMAN IL-3 RECEPTOR ALPHA CHAIN Public/Granted day:2016-09-29
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