Invention Grant
- Patent Title: Human carbonic anhydrase II with increased physical stability
- Patent Title (中): 人类碳酸酐酶II具有增加的物理稳定性
-
Application No.: US14382462Application Date: 2013-04-11
-
Publication No.: US09540625B2Publication Date: 2017-01-10
- Inventor: Uno Carlsson , Martin Karlsson
- Applicant: Inzymes Biotech AB
- Applicant Address: SE Linkoping
- Assignee: Inzymes Biotech AB
- Current Assignee: Inzymes Biotech AB
- Current Assignee Address: SE Linkoping
- Agency: Harness, Dickey & Pierce, P.L.C.
- Priority: SE1250400 20120423
- International Application: PCT/SE2013/050392 WO 20130411
- International Announcement: WO2013/162445 WO 20131031
- Main IPC: C12N9/88
- IPC: C12N9/88 ; C07H21/04 ; B01D53/84
Abstract:
An isolated polypeptide having carbonic anhydrase activity, the sequence of which corresponds to modified human carbonic anhydrase II is described. The isolated polypeptide comprises the mutations A23C, S99C, L202C, C205S and V241C and the polypeptide has increased physical stability compared to wild type carbonic anhydrase II. Further, the polypeptide comprises disulfide bridges between C23 and C202 and/or between C99 and C241.
Public/Granted literature
- US20150191711A1 HUMAN CARBONIC ANHYDRASE II WITH INCREASED PHYSICAL STABILITY Public/Granted day:2015-07-09
Information query
